BUSINESS
First Oral Small-Molecule GLP-1 Nears Filing; Broad Use Expected in Diabetes
The world’s first small-molecule GLP-1 receptor agonist is approaching regulatory filing. Orforglipron, originated by Chugai Pharmaceutical and licensed to Eli Lilly, is expected to be submitted for approval in obesity by year-end and in type 2 diabetes in 2026, with…
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The Wednesday TableShe had been on virtual calls since eight in the morning. The screen glowed. Her eyes burned. Plugged into Teams across time zones, she was digitally connected yet entirely isolated from the reality of Japan’s pharma market.She needed…





